Cushing's syndrome and pituitary-adrenal suppression due to clobetasol propionate.
نویسندگان
چکیده
Widespread application of clobetasol propionate resulted in suppression of the hypothalamic pituitary axis in four patients. Three patients showed Cushigoid features and developed symptoms of adrenocortical insufficiency on withdrawal of clobetasol.
منابع مشابه
Iatrogenic Cushing\'s Syndrome Due to Cutaneous Corticosteroid Therapy
Summary A case of Cushing' s syndrome associated with application of topical clobetasol propionate (0.05%) is reported. Local application of clobetasol propionate is associated with adrenal suppression in normal subjects and on this basis, it has been recommended that less than 50 g per week be used. There have been sporadic case reports of cushing's syndrome associated with topical steroid bu...
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متن کاملEffect on adrenal function of topically applied clobetasol propionate (Dermovate).
Thirty-nine patients (15 outpatients and 24 inpatients) with a variety of skin diseases affecting variable areas of the body surface were treated with clobetasol propionate ointment (Dermovate). Before and after treatment the adrenal response to an intramuscular injection of tetracosactrin was rested and additional 9 am plasma cortisol levels were measured at intervals during treatment. A satis...
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ورودعنوان ژورنال:
- British medical journal
دوره 2 5968 شماره
صفحات -
تاریخ انتشار 1975